Bolaamphiphile-based supramolecular gels with drugs eliciting membrane effects

Supramolecular chemistry has garnered important interest in recent years toward improving therapeutic efficacy via drug delivery approaches. Although self-assemblies have been deeply investigated, the design of novel drugs leveraging supramolecular is less known. In this contribution, we show that a Low Molecular Weight Gel (LMWG) can elicit cancer cell apoptosis. This biological effect results from unique properties bolaamphiphile-based gelator, which allow for strong interaction with lipid membrane. supramolecular-drug paradigm opens up new possibilities applications targeting membrane lipids.